杨茂华    副研究员

                 学历/学位：研究生/博士

                 研究方向：环境微生物及生物基化学品合成

                 邮箱：mhyang@ipe.ac.cn

                 地址：北京市海淀区中关村北二街1号

                 邮编：100190

简历介绍：

杨茂华，博士，副研究员，硕士生导师。2011年获中科院过程工程研究所博士学位，2011年7月至今，在中科院过程工程研究所工作。研究方向是微生物代谢改造及平台化合物合成，开展了大肠杆菌、酵母、硫碱弧菌等微生物的代谢工程和工程化应用研究，实现了丙酮酸、丁二酸等大宗化学品的高效生物合成以及沼气等微生物脱硫的应用基础研究。

代表论著：

1. 赵秀梅, 杨茂华*, 穆廷桢, 刘金龙, 邢建民. 电缆细菌及其介导的生电硫氧化（e-SOx）过程研究. 应用与环境生物学报, 2022, 6(27): 247-253

2. 杨茂华*, 穆廷桢, 苗得露, 刘金龙, 张翔, 邢建民. 盐碱湖硫循环及嗜盐嗜碱硫功能菌研究. 应用与环境生物学报, 2021, 3(27): 1-25

3. ZX Liu, MH Yang*, TZ Mu, JL Liu, JM Xing. Transcriptional response of Thialkalivibrio versutus D301 to different sulfur sources and identification of the sulfur oxidation pathways. J Biotechnol, 2021, 329(10): 160-169

4. 刘志霞, 杨茂华*, 穆廷桢, 刘金龙, 邢建民. 表面活性剂对嗜盐嗜碱硫碱弧菌D301生成及利用硫颗粒的影响.微生物学通报, 2021, 48(2):362-372

5. 李向园,杨茂华*,穆廷桢,刘金龙,赵国群,邢建民.一株嗜盐嗜碱硫氧化菌的筛选、鉴定及硫氧化特性.微生物学通报,2020, 47(8):2372-2381

6. Yang, Maohua; Chen, Ruonan; Mu, Tingzhen; Zhang, Xiang; Xing, Jianmin*, Switch on a more efficient pyruvate synthesis pathway based on transcriptome

analysis and metabolic evolution, Journal of bioscience and bioengineering, 2017.11, 124(5): 523~527

7. Yang, M.; Mu, T.; Zhong, W.; Olajuyin, A. M.; Xing, J. *,Analysis ofgluconate metabolism for pyruvate production in engineered Escherichia colibased on genome-wide transcriptomes, Letter in applied microbiology, 2017.8,65(2): 165~172

8. Yang, Maohua; Xing, Jianmin*, Improvement of pyruvate production based on regulation of intracellular redox state in engineered Escherichia coli , Biotechnology and bioprocess engineering, 2017.8, 22(4): 376~381

9. Maohua Yang*; Xiang Zhang, Construction of pyruvate producing strainwith intact pyruvate dehydrogenase and genome-wide transcription analysis, World Journal of Microbiology and Biotechnology, 2016.11.23, 33: 59~67

10. Yilan Liu; Maohua Yang; Jinjin Chen; Daojiang Yan; Wanwan Cheng; Yanyan Wang; Anders Thygesen; Ruonan Chen; Jianmin Xing* ; Qinhong Wang ; Yanhe Ma*, PCR-Based Seamless Genome Editing with High Efficiency and Fidelity in

Escherichia coli, PLos One, 2016.2.4, 11(3): e0149762

11. Maohua Yang; Jianmin Xing* ; Yuyang Liu; Yilan Liu; Tingzhen Mu; Jiemin Zhou, Formation and characterization ofpseudo-lignin microspheres during high-pressure water pretreatment, BioResources, 2015. 10(4): 8474~8486

12. Maohua Yang; Aimin Zhang; Binbin Liu; Wangliang Li; Jianmin Xing*, Improvement of cellulose conversion caused by the protection of Tween-80 on the adsorbed cellulase , Biochemical Engineering Journal, 2011.10.15, 56(3):125~129

13. Maohua Yang; Wangliang Li; Binbin Liu; Qiang Li; Jianmin Xing*, High-concentration sugars production from corn stover based on combined pretreatmentsand fed-batch process , Bioresource Technology, 2010.7, 101(13): 4884~4888